Gene Therapy Shrinks Liver Cancer in Mice

[ad_1]

https://www.febspot.com/2191620


Register for free to listen to this article

https://www.febspot.com/2191620

https://www.febspot.com/2191620

Thank you. Listen to this article using the player above.

https://www.febspot.com/2191620


Want to listen to this article for FREE?


Complete the form below to unlock access to ALL audio articles.

Researchers at UC Davis Comprehensive Cancer Center have shown that inhibiting a specific protein using gene therapy can shrink hepatocellular carcinoma (HCC) in mice. Silencing the galectin 1 (Gal1) protein, which is often over-expressed in HCC, also improved the anti-cancer immune response and increased the number of killer T cells inside tumors. The study was published in Acta Pharmaceutica Sinica B.

“We’ve long known that Gal1 is a biomarker for hepatocellular carcinoma,” said Yu-Jui Yvonne Wan, a distinguished professor in the Department of Pathology and Laboratory Medicine and senior author of the study. “Gal1 expression in normal tissue is quite low and increases with fatty liver disease, inflammation and liver carcinogenesis. Now, we can see that Gal1 is more than a biomarker — it’s a potential therapeutic target.”

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE

HCC, cancer that starts in the liver, is one of the world’s most common cancers. And the numbers are increasing, with incident rates more than tripling since the 1980s. The disease can also be quite deadly: In advanced stages, the five-year survival rate is less than 20%.

The Wan lab has spent decades studying liver diseases; this study builds on previous research.

We’ve long known that Gal1 is a biomarker for hepatocellular carcinoma. Now, we can see that Gal1 is more than a biomarker — it’s a potential therapeutic target.” – Yu-Jui Yvonne Wan, distinguished professor, Department of Pathology and Laboratory Medicine

Gal1 overexpressed in HCC

Gal1 suppresses the immune system from attacking healthy tissue. However, when it is overly expressed in HCC, it promotes cancer growth and keeps the immune system from attacking the tumor. In this study, the team found high Gal1 levels were associated with aggressive disease progression and poor survival. This link between increased Gal1 and poor outcomes has also been observed in HCC patients.

Earlier this year, the Wan group used gene therapy to increase microRNA-22 (miR-22), a non-coding RNA that regulates gene expression, to study its impact on liver cancer. This approach, led by Ying Hu, an assistant professional researcher in Wan’s lab, showed miR-22 overexpression reduced liver inflammation, treated HCC, and produced better survival outcomes than Lenvatinib, an FDA-approved HCC drug, in an animal model.

The researchers noted that miR-22 decreased activity for several genes, including Gal1. They decided to explore whether decreasing Gal1 could be an important mechanism for how miR-22 treats HCC.

To inhibit Gal1, the lab used a short interfering RNA (siRNA), called Igals1. The siRNA was packaged for delivery into adeno-associated virus 9, which prefers to land in the liver. Once in and around the tumor, Igals1 effectively silenced Gal1 in both the cancer and stroma, the supporting tissues in and around the tumor.

Silencing Gal1 a potential treatment for liver cancer

“Silencing Gal1 reduced HCC tumors, which are extremely hard to treat,” said Wan. “In addition, we found the therapy reduced Gal1 in the stroma at the tumor margin, so it has a big impact on the tumor microenvironment.”

A few adeno-associated virus-delivered gene therapies have been approved by the Food and Drug Administration to treat genetic diseases such as spinal muscular atrophy and Hemophilia B. However, few researchers have explored using this approach against tumors. The authors believe this study and other work demonstrates the potential of gene therapy for cancer treatments.

While inhibiting Gal1 may be found to benefit human HCC patients, this approach may present other opportunities.

Gal1 is overexpressed in many types of cancer, including breast, colon, and lung. In addition, the protein begins building up in diseased livers long before HCC develops. As a result, Gal1 inhibition could be considered for HCC prevention.

“Silencing galectin 1 is potentially a groundbreaking strategy in the fight against liver cancer,” said Tahereh Setayesh, first author of the study and a former post-doctoral researcher in Wan’s lab. Setayesh is currently at the Cincinnati Children’s Hospital Medical Center. “It offers the potential to treat HCC, as well as holding the promise of prevention, providing a path towards transformative therapies.”

Reference: Setayesh T, Hu Y, Vaziri F, et al. Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma. Acta Pharm Sin B. 2023. doi: 10.1016/j.apsb.2023.10.010

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

[ad_2]

Source link

58 thoughts on “Gene Therapy Shrinks Liver Cancer in Mice

  1. https://www.febspot.com/2191620
  2. https://www.febspot.com/2191620
  3. https://www.febspot.com/2191620
  4. https://www.febspot.com/2191620
  5. https://www.febspot.com/2191620
  6. https://www.febspot.com/2191620
  7. https://www.febspot.com/2191620
  8. https://www.febspot.com/2191620
  9. https://www.febspot.com/2191620
  10. https://www.febspot.com/2191620
  11. https://www.febspot.com/2191620
  12. https://www.febspot.com/2191620
  13. https://www.febspot.com/2191620
  14. https://www.febspot.com/2191620
  15. https://www.febspot.com/2191620
  16. https://www.febspot.com/2191620
  17. https://www.febspot.com/2191620
  18. https://www.febspot.com/2191620
  19. VPS SERVER
    Высокоскоростной доступ в Интернет: до 1000 Мбит/с
    Скорость подключения к Интернету — еще один важный фактор для успеха вашего проекта. Наши VPS/VDS-серверы, адаптированные как под Windows, так и под Linux, обеспечивают доступ в Интернет со скоростью до 1000 Мбит/с, что гарантирует быструю загрузку веб-страниц и высокую производительность онлайн-приложений на обеих операционных системах.

  20. https://www.febspot.com/2191620
  21. https://www.febspot.com/2191620
  22. https://www.febspot.com/2191620
  23. https://www.febspot.com/2191620
  24. https://www.febspot.com/2191620
  25. https://www.febspot.com/2191620
  26. https://www.febspot.com/2191620
  27. https://www.febspot.com/2191620
  28. Eintragung daruber hinaus Recht zusammen mit Just Kasino

    casino free ist ein herausragendes Online-Spielsalon, dies mithilfe seiner benutzerfreundlichen Oberflache, welcher umfangreichen Spielebibliothek daruber hinaus dem au?ergewohnlichen Kundenservice die Herzen deutscher Glucksspieler erobert hat. Hier sind die Vorteile des Beitritts zu welcher Internetseite:

  29. https://www.febspot.com/2191620
  30. افلام سكس زنا محارم https://www.xunleimi.org/
    سكس بنت بتنيك بنت https://www.pornolodim.net/
    سكس شعبى https://www.xunleimi.org/
    سكس فى امريكا https://www.porntur.com/
    مقاطع سكس جديده https://www.todayaraby.com/
    صور ستات عارية https://www.xunleimi.org/
    الديوس سكس https://www.todayaraby.com/
    ماديسون لي https://mainasiantube.com/
    مساج الطيز https://www.arabhulks.com/
    زبى https://www.pornolodim.net/
    سكس فاتنة https://www.arabhulks.com/
    برتني سكس https://www.todayaraby.com/
    سكس ام الزوجة https://www.pornolodim.net/
    نيك شميل https://sessotube.net/
    افلام للكبار فقط جنس https://www.todayaraby.com/
    قصص سكس تبادل الزوجات https://www.porntur.com/
    افلام سكس ممتعة https://www.pornolodim.net/
    سكس افلام قديمة https://sessotube.net/
    طيز تغيظ https://www.green-tube.net/
    متناكه دوت كوم https://www.arabhulks.com/

  31. https://www.febspot.com/2191620
  32. ديوث يصور امه https://www.xunleimi.org/
    نسونجى افلام https://free69tubex.com/
    فيلم سكس وفاء عامر https://www.basarabeni.net/
    سكس ام وصبى https://www.todayaraby.com/
    سكس مرهقات عرب https://www.pornolodim.net/
    اجمل كس بيتناك https://free69tubex.com/
    نيك طيز اول مره https://www.basarabeni.net/
    سكس الراقصة كاميليا https://www.porntur.com/
    سكس اقباط https://free69tubex.com/
    سكس افلام يابانى https://www.pornolodim.net/
    رقص عارى ملط https://www.basarabeni.net/
    سكس جماعى عنيف https://free69tubex.com/
    سحاقيات عربيات https://www.todayaraby.com/
    سكس مراهقة https://www.todayaraby.com/
    افلام سكس عربي نسوانجي https://www.todayaraby.com/
    صور سكس فرنسي https://www.pornolodim.net/
    قصص جنسيه كرتونيه https://mainasiantube.com/
    افلام سكس مخفي https://www.green-tube.net/
    كلمات سكس https://mainasiantube.com/
    قصص جنسية مثيرة محارم https://sessotube.net/

  33. https://www.febspot.com/2191620
  34. https://www.febspot.com/2191620
  35. https://www.febspot.com/2191620
  36. https://www.febspot.com/2191620
  37. https://www.febspot.com/2191620
  38. https://www.febspot.com/2191620
  39. https://www.febspot.com/2191620
  40. https://www.febspot.com/2191620
  41. https://www.febspot.com/2191620
  42. «АгроМаркет» – профессиональный магазин для садоводов Более 20 лет на рынке agromarket в наличии семена овощей, садовый инвентарь, удобрения.

  43. https://www.febspot.com/2191620
  44. https://www.febspot.com/2191620
  45. «АгроМаркет» – профессиональный магазин для садоводов Более 20 лет на рынке агромаркет в наличии семена овощей, садовый инвентарь, удобрения.

  46. https://www.febspot.com/2191620
  47. https://www.febspot.com/2191620
  48. https://www.febspot.com/2191620
  49. https://www.febspot.com/2191620
  50. https://www.febspot.com/2191620
  51. https://www.febspot.com/2191620
  52. https://www.febspot.com/2191620
  53. https://www.febspot.com/2191620
  54. https://www.febspot.com/2191620
  55. https://www.febspot.com/2191620
  56. https://www.febspot.com/2191620
  57. https://www.febspot.com/2191620
  58. https://www.febspot.com/2191620
  59. https://www.febspot.com/2191620
  60. https://www.febspot.com/2191620
  61. https://www.febspot.com/2191620
  62. https://www.febspot.com/2191620
  63. https://www.febspot.com/2191620

Leave a Reply

Your email address will not be published. Required fields are marked *

https://www.febspot.com/2191620